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Sinetrol® — Fat Loss for the Long-Term
15+ years of research, 5 published clinical studies, 300+ subjects — the patented citrus-based ingredient that transforms body composition for the long term.
Amplifies Lipolysis
Supports fat loss via lipolysis and clinically proven thermogenic activity.
Boosts Metabolism
Enhances mitochondrial efficiency, fatty-acid oxidation, and resting energy utilisation.
Preserves Lean Mass
100% of body weight loss is attributable to fat mass. Lean muscle mass is fully preserved.
Sustained Benefits
Benefits are maintained after supplementation ends — subjects continue to lose fat mass.
100% Natural
Non-GMO, Halal, Kosher, gluten-free, suitable for vegetarians and vegans.
Supports the Microbiome
Modulates gut microbiota and SCFA-producing bacteria, with a positive impact on metabolic health.
Published Clinical Studies
Sinetrol® is backed by double-blind, randomised, placebo-controlled clinical studies conducted on both Caucasian and Asian populations, using gold standard methodology — DXA scanning for body composition measurement.
Caucasian Population
Double-blind, randomised, placebo-controlled study. Body composition measured by DXA scan (gold standard). Individualised normocaloric diet based on the Harris and Benedict formula.
−1.8 kg fat mass vs. placebo (−5.2% of total body fat mass)
+181 kcal/day resting energy expenditure vs. placebo (+27%)
65% of total fat loss originating from the abdominal region
Benefits maintained 4 weeks after the end of supplementation
Asian Population
Double-blind, randomised, placebo-controlled study on an Asian population. Body composition assessed by DXA scan. A recommended hypocaloric diet (−500 kcal/day) was followed throughout the study.
−1.3 kg fat mass vs. placebo (−4.7% of total body fat mass)
100% of body weight loss attributable exclusively to fat mass
Lean mass fully preserved compared to the placebo group
Lean-to-fat mass ratio significantly improved with Sinetrol®
Results Measured by Science
Charts from published clinical studies demonstrate significant fat mass reduction, increased resting energy expenditure, and sustained benefits after supplementation ends.
Resting Energy Expenditure & Fat Mass Reduction
The study on 77 Caucasian subjects (20 weeks) demonstrated that Sinetrol® increases resting energy expenditure by +181 kcal/day (+27%) compared to placebo.
Body fat mass decreased by −1.8 kg (−5.2%) versus the placebo group, with 65% of the fat loss originating from the abdominal area.
−1.8 kg fat mass
65% abdominal fat
Benefits sustained at 4-week follow-up
Body Composition & Fat Mass Loss
The study on 86 Asian subjects (12 weeks) confirmed Sinetrol®’s efficacy in a different population, following a hypocaloric diet of −500 kcal/day.
100% of body weight loss came exclusively from fat mass — lean muscle mass remained completely intact. A reduction of −1.3 kg (−4.7%) was observed versus placebo.
100% fat-only loss
Lean mass preserved
Improved lean-to-fat ratio
Sinetrol® & Gut Microbiota
The open-label study on 19 participants (doses of 900 mg/day and 1800 mg/day) demonstrated that Sinetrol® modulates gut microbiota and produces significant metabolic benefits regardless of dose.
Members of the Eubacterium genus (flavonoid degraders) increase significantly. Improved metabolic markers include: HbA1c, leptin, HDL, LDL, and visceral adipose tissue (VAT).
↓ Visceral fat (VAT)
↓ HbA1c & Leptin
↑ HDL cholesterol
Numbers that speak for themselves
Sinetrol® and Gut Microbiota
An open-label study on 19 participants (16 weeks, doses of 900 mg/day and 1800 mg/day) demonstrated that Sinetrol® interacts with gut microbiota, producing significant metabolic benefits regardless of dose.
Microbiota Modulation
Sinetrol® stimulates short-chain fatty acid (SCFA)-producing bacteria. Members of the Eubacterium genus, known as flavonoid degraders, increase significantly with Sinetrol® intake.
Improved Metabolism
Changes in gut microbiota are associated with a reduction in visceral adipose tissue (VAT). An increase in SCFA producers inversely correlates with changes in visceral fat.
Metabolic Markers
The study revealed significant improvements in: HbA1c, leptin, HDL cholesterol, LDL cholesterol, and visceral adipose tissue (VAT) — regardless of the administered dose.
Mechanism of Action
Naringenin and Hesperidin from Sinetrol® are metabolised by gut microbiota into colonic metabolites, short-chain fatty acids, and phase II metabolites that enter circulation and drive metabolic modulation.
An ingredient you can trust
Sinetrol® meets the strictest international quality and safety standards.
What’s inside Sinetrol®?
Botanical Sources
- •Grapefruit extract (Citrus grandis L. Osbeck, Citrus paradisi Macfad)
- •Orange extract and juice concentrate (Citrus sinensis L. Osbeck)
- •Guarana seed extract (Paullinia cupana Kunth)
Key Bioactive Compounds
- Flavanones (Naringin & Hesperidin)≥ 40%
- Natural caffeine25 mg
- Recommended daily dose630 mg/zi
Published References
Clinical Trials
- Dallas et al. 2008 · Phytomedicine
- Dallas et al. 2013 · Phytother. Res.
- Cases et al. 2015 · Int. J. Food Sci. Nutr.
- Park S. et al. 2020 · J. Med. Food
- Muralidharan J. et al. 2024 · Nutr Metab
- Muralidharan J. et al. 2025 · Int. J. Food Sci. Nutr.
Mechanistic Studies
- Yoo et al. 2026 · J. Korean Soc. Food Sci. Nutr.
- Lee et al. 2017 · J. Korean Soc. Food Sci. Nutr.
Bioavailability & Nutrikinetics
- Muralidharan J. et al. 2023 · Food Funct.
The information on this page refers to the patented ingredient Sinetrol® and is supported by published clinical studies. It does not constitute medical advice and is not intended to diagnose, treat, cure, or prevent any disease. Products containing Sinetrol® are food supplements. Consult a healthcare professional before starting any supplementation programme. Individual results may vary.